Bacterial Resistance to Antimicrobials

Resistance to antimicrobials in humans and animals.

Warning signs of antimicrobial resistance, chinks in the antimicrobial armour, began to appear in the middle of the last century, and by the 1990s various reports had signalled the dangers of excessive or inappropriate use of antibiotics in clinical medicine and of the use of antibiotics in animal feed as growth promoters. Overuse of antimicrobials emerged as the main culprit, and reducing thei...

Poster 1 Peptidoglycan Hydrolase Antimicrobials Engineered to Reduce Resistance Development

Staphylococcus aureus resistance to topical antimicrobials in atopic dermatitis*

Background: Topical antimicrobial drugs are indicated for limited superficial pyodermitis treatment, although they are largely used as self-prescribed medication for a variety of inflammatory dermatoses, including atopic dermatitis. Monitoring bacterial susceptibility to these drugs is difficult, given the paucity of laboratory standardization. Objective: To evaluate the prevalence of Staphyl...

Resistance to Antimicrobials Mediated by Efflux Pumps in Staphylococcus aureus

Resistance mediated by efflux has been recognized in Staphylococcus aureus in the last few decades, although its clinical relevance has only been recognized recently. The existence of only a few studies on the individual and overall contribution of efflux to resistance phenotypes associated with the need of well-established methods to assess efflux activity in clinical isolates contributes grea...

Induction of mycobacterial resistance to quinolone class antimicrobials.

An agar plate assay was developed for detecting the induction of drug-resistant mycobacterial mutants during exposure to inhibitors of DNA gyrase. When Mycobacterium smegmatis on drug-containing agar, resistant colonies arose over a period of 2 weeks. A recA deficiency reduced mutant recovery, consistent with involvement of the SOS response in mutant induction. The C-8-methoxy compounds gatiflo...